RRAD
Description
The RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator) is a protein-coding gene located on chromosome 16.
RRAD is a human gene.
RRAD plays a crucial role in regulating calcium influx in cardiomyocytes, influencing heart rate and contractile force. It can both enhance and suppress L-type calcium currents, potentially contributing to cardiac antiarrhythmia. Additionally, RRAD regulates the trafficking of calcium channels to the cell membrane and inhibits cardiac hypertrophy through the CaMKII pathway.
RRAD is also known as RAD, RAD1, REM3.
Associated Diseases
- Brugada syndrome
- dilated cardiomyopathy 1I
- familial atrial fibrillation
- arrhythmogenic right ventricular dysplasia 10
- dilated cardiomyopathy 1L
- cardiomyopathy, dilated, 2F
- arrhythmogenic right ventricular dysplasia 5
- hypertrophic cardiomyopathy 6
- catecholaminergic polymorphic ventricular tachycardia 1
- dilated cardiomyopathy 1II
