RPS8
Description
The RPS8 (ribosomal protein S8) is a protein-coding gene located on chromosome 1.
RPS8 is a human gene encoding a protein that is a component of the small 40S ribosomal subunit, which is essential for protein synthesis. The protein belongs to the S8E family of ribosomal proteins and is located in the cytoplasm. Increased expression of RPS8 has been observed in colorectal tumors and polyps compared to normal colonic mucosa. This gene is co-transcribed with several small nucleolar RNA genes, and there are multiple processed pseudogenes of this gene dispersed throughout the genome.
RPS8 is a component of the small ribosomal subunit, which is responsible for protein synthesis in the cell. It is also part of the small subunit (SSU) processome, the first precursor of the small eukaryotic ribosomal subunit. During SSU processome assembly in the nucleolus, RPS8 interacts with other ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins to facilitate RNA folding, modifications, rearrangements, and cleavage. This process also involves targeted degradation of pre-ribosomal RNA by the RNA exosome.
RPS8 is also known as S8, eS8.
Associated Diseases
- Duchenne muscular dystrophy
- cystic fibrosis
- COVID-19
- Becker muscular dystrophy
- qualitative or quantitative defects of dystrophin
- aniridia
- hemophilia B
- Alport syndrome
- hemophilia A
- cystinosis
