RPS13
Description
The RPS13 (ribosomal protein S13) is a protein-coding gene located on chromosome 11.
RPS13, the human gene encoding 40S ribosomal protein S13, is responsible for producing a protein that is a vital part of the small 40S ribosomal subunit, a key component of the cellular machinery for protein synthesis. The protein belongs to the S15P family of ribosomal proteins and is located in the cytoplasm. It has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog, ribosomal protein S15, is involved in the early stages of ribosome assembly. The RPS13 gene is co-transcribed with two U14 small nucleolar RNA genes located within its third and fifth introns. Like many genes that code for ribosomal proteins, there are multiple processed pseudogenes of RPS13 scattered throughout the genome.
RPS13 is a component of the small ribosomal subunit (SSU) which is involved in protein synthesis within the cell. As part of the SSU processome, a precursor to the small eukaryotic ribosomal subunit, RPS13 plays a role in the assembly process within the nucleolus. This involves interactions with other proteins, RNA chaperones, and the nascent pre-rRNA. Together, they ensure proper RNA folding, modifications, rearrangements, and cleavage. The RNA exosome also participates in this process by degrading pre-ribosomal RNA.
RPS13 is also known as S13, uS15.
Associated Diseases
- Duchenne muscular dystrophy
- cystic fibrosis
- COVID-19
- Becker muscular dystrophy
- qualitative or quantitative defects of dystrophin
- aniridia
- Alport syndrome
- cystinosis
- hemophilia A
- hemophilia B
