RPL7
Description
The RPL7 (ribosomal protein L7) is a protein-coding gene located on chromosome 8.
RPL7 is a gene that encodes a ribosomal protein, a component of the large 60S subunit of ribosomes, the cellular machinery responsible for protein synthesis. The protein belongs to the L30P family and contains a BZIP-like domain that mediates homodimerization and binding to DNA and RNA, particularly 28S rRNA and mRNA. It has been implicated in regulating translation by inhibiting cell-free translation of mRNAs. RPL7 is located in the cytoplasm and is recognized as an autoantigen in autoimmune diseases like systemic lupus erythematosus. The gene has multiple processed pseudogenes dispersed throughout the genome.
RPL7 is a component of the large ribosomal subunit, which is responsible for protein synthesis in the cell. It binds to G-rich structures in 28S rRNA and mRNA, and plays a regulatory role in translation by inhibiting cell-free translation of mRNAs.
RPL7 is also known as L7, humL7-1, uL30.
Associated Diseases
- Duchenne muscular dystrophy
- cystic fibrosis
- Becker muscular dystrophy
- qualitative or quantitative defects of dystrophin
- aniridia
- Alport syndrome
- cystinosis
- hemophilia A
- hemophilia B
