RPL32
Description
The RPL32 (ribosomal protein L32) is a protein-coding gene located on chromosome 3.
RPL32 is a gene that encodes for a protein called 60S ribosomal protein L32. This protein is a component of the large (60S) subunit of the ribosome, which is responsible for protein synthesis. The ribosome is made up of two subunits, a small (40S) subunit and a large (60S) subunit. There are approximately 80 different proteins and 4 RNA molecules that make up the ribosome. RPL32 is a member of the L32E family of ribosomal proteins and is located in the cytoplasm. While some studies have placed the RPL32 gene on chromosome 3, between positions 13.3 and 21, it is believed to be located between positions 25 and 24 on the short arm of chromosome 3. There are multiple copies of this gene scattered throughout the genome, which are known as pseudogenes. Different versions of the RPL32 gene have been found that produce the same protein, but these versions differ in their splicing pattern.
RPL32 is a component of the large ribosomal subunit, which is responsible for protein synthesis in the cell. (PMID:23636399, PMID:32669547)
RPL32 is also known as L32, PP9932, eL32.
Associated Diseases
- Duchenne muscular dystrophy
- cystic fibrosis
- Becker muscular dystrophy
- qualitative or quantitative defects of dystrophin
- aniridia
- hemophilia B
- cystinosis
- hemophilia A
- Alport syndrome
- breast cancer
- alpha thalassemia-intellectual disability syndrome type 1
