RPL13
Description
The RPL13 (ribosomal protein L13) is a protein-coding gene located on chromosome 16.
RPL13, also known as 60S ribosomal protein L13, is a protein that plays a crucial role in protein synthesis. It is a component of the large ribosomal subunit (60S), which along with the small ribosomal subunit (40S) forms the ribosome. The ribosome is the cellular machinery responsible for translating genetic information from messenger RNA (mRNA) into proteins. RPL13 belongs to the L13E family of ribosomal proteins and is located in the cytoplasm. The gene encoding RPL13 shows higher expression in benign breast lesions compared to breast carcinomas. Multiple transcript variants exist, which arise from alternative splicing and/or polyadenylation, all encoding the same protein. RPL13 has been shown to interact with CDC5L. RPL13 is also associated with bone development.
RPL13 is a component of the ribosome, a large ribonucleoprotein complex essential for protein synthesis. The ribosome is composed of two subunits: a small subunit (SSU) and a large subunit (LSU). The SSU binds messenger RNAs (mRNAs) and translates the encoded genetic message by selecting the appropriate aminoacyl-transfer RNA (tRNA) molecules. The LSU contains the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, linking amino acids delivered by tRNAs to form a polypeptide chain. Newly synthesized polypeptides exit the ribosome through a tunnel in the LSU and interact with protein factors that facilitate processing, targeting, and membrane insertion. As part of the LSU, RPL13 is likely involved in its formation and the maturation of ribosomal RNAs (rRNAs). RPL13 has also been implicated in bone development.
RPL13 is also known as BBC1, D16S444E, D16S44E, L13, SEMDIST, eL13.
