RPH3A
Description
The RPH3A (rabphilin 3A) is a protein-coding gene located on chromosome 12.
Rabphilin-3A is a protein encoded by the RPH3A gene in humans. It contains two C2 domains and binds calcium ions at low micromolar concentrations. It has been shown to regulate neurotransmitter release in hippocampal neurons after an increase in synaptic activity and a subsequent decrease in release rate.
Rabphilin-3A, also known as Exophilin-1, is crucial for regulated exocytosis, particularly in the docking and fusion steps. At the presynaptic site, it is recruited by RAB3A to the synaptic vesicle membrane, facilitated by GTP, where it modulates synaptic vesicle trafficking and neurotransmitter release triggered by calcium. In the postsynaptic region, it forms a complex with GRIN2A and DLG4, impacting the stability of NMDA receptors. Additionally, it participates in the exocytosis of arginine vasopressin hormone.
RPH3A is also known as -.
