RPA2
Description
The RPA2 (replication protein A2) is a protein-coding gene located on chromosome 1.
Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene.
The RPA2 gene encodes a protein that, as part of the replication protein A (RPA) complex, binds and stabilizes single-stranded DNA intermediates formed during DNA replication or DNA stress. This prevents re-annealing of the strands, while recruiting and activating proteins and complexes involved in DNA metabolism. RPA2 plays a critical role in both DNA replication and the cellular response to DNA damage. In this response, RPA2 controls DNA repair and DNA damage checkpoint activation, and through the recruitment of ATRIP activates the ATR kinase, a key regulator of DNA damage response. RPA2 is also required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, and for the recruitment of proteins involved in nucleotide excision repair, such as XPA and XPG. RPA2 also participates in base excision repair (BER), likely through interaction with UNG. RPA2 recruits SMARCAL1/HARP, involved in replication fork restart, to sites of DNA damage and may also play a role in telomere maintenance.
RPA2 is also known as REPA2, RP-A p32, RP-A p34, RPA32.
