RNF7
Description
The RNF7 (ring finger protein 7) is a protein-coding gene located on chromosome 3.
RNF7 is a highly conserved ring finger protein that plays a critical role in protein degradation. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are involved in cell cycle progression and signal transduction. RNF7 interacts with and is a substrate of casein kinase II (CSNK2A1/CKII). Phosphorylation of RNF7 by CSNK2A1 promotes the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Different isoforms of RNF7 have been reported due to alternative splicing.
RNF7, also known as RBX2, is a crucial component of various cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes) that regulate protein degradation. These complexes control diverse cellular processes, including cell cycle progression, signal transduction, and transcription. The ECS complexes' specificity is determined by their unique substrate recognition component, which contains a SOCS box domain. RNF7 recruits E2 ubiquitination enzymes to the complex via its RING-type domain, bringing them close to the substrate. It promotes the neddylation of CUL5 through its interaction with UBE2F. RNF7 is involved in various specific functions, such as regulating reelin signaling by mediating DAB1 ubiquitination and degradation as part of the ECS(SOCS7) complex. It also contributes to the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR within the ECS(SOCS2) complex. RNF7 regulates Ras protein signal transduction by promoting the ubiquitination and degradation of NF1. Additionally, it participates in the ubiquitination and degradation of CKB within the ECS(ASB9) complex, nuclear CGAS within the ECS(SPSB3) complex, and BTRC in some ECS complexes. RNF7 collaborates with ARIH2 in ubiquitinating target proteins, with ARIH2 mediating the initial ubiquitin addition. While RNF7 preferentially interacts with CUL5, it may also interact with CUL1, CUL2, CUL3, CUL4A, and CUL4B, although further confirmation is required. RNF7 is vital for cell protection against apoptosis induced by redox agents.
RNF7 is also known as CKBBP1, ROC2, SAG, rbx2.
