RNF5
Description
The RNF5 (ring finger protein 5) is a protein-coding gene located on chromosome 6.
RNF5 is an enzyme that plays a role in regulating cell processes through ubiquitination. It contains a RING finger motif, known for protein interactions, and acts as a membrane-bound ubiquitin ligase. RNF5 can regulate cell motility by modifying paxillin, a protein involved in cell adhesion, through ubiquitination.
RNF5 is a membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins. It may work with the E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. RNF5 regulates cell motility and localization of PXN/paxillin by mediating its ubiquitination. It also ubiquitinates Salmonella type III secreted protein sopA. RNF5 mediates 'Lys-63'-linked polyubiquitination of JKAMP, regulating its function by decreasing its association with the proteasome and ERAD, likely involving the E2 ubiquitin-conjugating enzyme UBE2N. RNF5 mediates 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150', leading to its proteasomal degradation in mitochondria after viral transfection, regulating antiviral responses. It also ubiquitinates and degrades ATG4B, inhibiting autophagy.
RNF5 is also known as RING5, RMA1.
