RNF41
Description
The RNF41 (ring finger protein 41) is a protein-coding gene located on chromosome 12.
RNF41, a human gene, encodes an E3 ubiquitin ligase called NRDP1. It contains a RING finger motif involved in protein-protein and protein-DNA interactions. Its precise function remains unclear, but three alternatively spliced variants produce two distinct isoforms. RNF41 interacts with USP8.
RNF41 acts as an E3 ubiquitin ligase, tagging target proteins for degradation. It specifically targets MYD88, suppressing pro-inflammatory cytokine production. RNF41 can also enhance the production of type I interferon via the TRIF pathway, potentially hindering viral infection. It activates TBK1 and IRF3, signaling molecules in immune responses. RNF41 regulates the levels of cytokine receptors like EPO and IL-3, influencing hematopoietic cell development. It maintains ERBB3 levels, preventing uncontrolled growth, and promotes apoptosis by degrading BIRC6. RNF41 modifies PRKN, accelerating its degradation, thus impacting the balance of cellular redox state. Importantly, RNF41-PRKN interaction is crucial for late mitophagy, a process essential for mitochondrial quality control.
RNF41 is also known as FLRF, NRDP1, SBBI03.
Associated Diseases
- endometrial cancer
- cryopyrin-associated periodic syndrome
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 3
- spermatogenic failure 31
- spermatogenic failure 26
- spermatogenic failure 61
- spermatogenic failure 23
