RNF4
Description
The RNF4 (ring finger protein 4) is a protein-coding gene located on chromosome 4.
RNF4 is a human gene that encodes a protein containing a RING finger domain, acting as a transcription factor. It interacts with and inhibits TRPS1, a suppressor of GATA-mediated transcription. RNF4 also interacts with ZNF278/PATZ1, reducing the enhancement of androgen receptor-dependent transcription. Mouse and rat studies suggest a role for RNF4 in spermatogenesis. RNF4 has been shown to interact with TCF20, PATZ1, and the Androgen receptor.
RNF4 is an E3 ubiquitin-protein ligase that binds polysumoylated chains covalently attached to proteins. It mediates 'Lys-6', 'Lys-11', 'Lys-48', and 'Lys-63'-linked polyubiquitination of these substrates, targeting them for proteasomal degradation. RNF4 regulates the degradation of various proteins including PML and the transcriptional activator PEA3. It's involved in chromosome alignment and spindle assembly, regulating the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI for proteasomal degradation. RNF4 regulates cellular responses to hypoxia and heat shock through degradation of EPAS1 and PARP1, respectively. Alternatively, it may bind DNA/nucleosomes and directly regulate transcription by enhancing basal transcription and steroid receptor-mediated transcriptional activation. RNF4 catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
RNF4 is also known as RES4-26, SLX5, SNURF.
Associated Diseases
- cancer
- 46,XY complete gonadal dysgenesis
- isolated congenital hypogonadotropic hypogonadism
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- ventricular septal defect 1
- 46,XX ovotesticular disorder of sex development
- Kennedy disease
- systemic lupus erythematosus
