RNF25
Description
The RNF25 (ring finger protein 25) is a protein-coding gene located on chromosome 2.
RNF25 is an enzyme that is encoded by the RNF25 gene in humans. It contains a RING finger motif and is involved in the regulation of protein degradation. The mouse version of this protein interacts with RELA, a subunit of NF-κB, and influences NF-κB-mediated transcription. It also binds to ubiquitin-conjugating enzymes (E2s) and can be ubiquitinated by E2s.
RNF25 is an E3 ubiquitin ligase that is essential for the RNF14-RNF25 translation quality control pathway. This pathway is activated when ribosomes stall during translation. RNF25 promotes the ubiquitination and degradation of translation factors on stalled ribosomes, including RPS27A, RPL0, RPL1, RPL12, RPS13, and RPS17. It also ubiquitinates and degrades stalled ETF1/eRF1. Beyond its role in the translation quality control pathway, RNF25 also promotes the ubiquitination and degradation of NKD2. Additionally, RNF25 may stimulate NF-κB-mediated transcription through its interaction with RELA/p65.
RNF25 is also known as AO7.
Associated Diseases
- dehydrated hereditary stomatocytosis
- familial pseudohyperkalemia
- microcytic anemia with liver iron overload
- hemolytic anemia due to glutathione reductase deficiency
- cholesterol-ester transfer protein deficiency
