RNF145
Description
The RNF145 (ring finger protein 145) is a protein-coding gene located on chromosome 5.
RNF145 is an E3 ubiquitin ligase that directly transfers ubiquitin from E2 enzymes to specific target proteins. It plays a crucial role in regulating cellular processes by controlling protein turnover. In response to bacterial infections, RNF145 negatively regulates the phagocyte oxidative burst by promoting the degradation of NADPH oxidase complex subunits, specifically CYBA and CYBB. This action helps to control the production of reactive oxygen species (ROS) that are essential for fighting infections. Additionally, RNF145 is involved in maintaining cholesterol homeostasis. When sterol levels are high, RNF145 ubiquitinates HMGCR, a key enzyme in cholesterol biosynthesis, leading to its degradation. This process requires the interaction of RNF145 with INSIG1. Furthermore, RNF145 can ubiquitinate SCAP, potentially inhibiting its transport to the Golgi apparatus and ultimately downregulating cholesterol biosynthesis.
RNF145 is also known as -.
