RNF144A
Description
The RNF144A (ring finger protein 144A) is a protein-coding gene located on chromosome 2.
RNF144A is a RING-between RING (RBR) family E3 ubiquitin ligase, closely related to RNF144B. It catalyzes ubiquitin linkages at K6-, K11-, and K48- positions of ubiquitin in vitro, regulated by self-association through its transmembrane domain. While its specific biological functions are largely unknown, RNF144A mutations have been found in various cancers including breast, stomach, lymphoma, glioblastoma, uterine, and lung cancers. RNF144A targets proteins involved in DNA repair, heat shock/chaperone function, and signaling for degradation, including DNA-PKcs, PARP1, HSPA2, BMI1, and RAF1.
RNF144A, also known as RING finger protein 144A, UbcM4-interacting protein 4, or Ubiquitin-conjugating enzyme 7-interacting protein 4, is an E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 and directly transfers it to targeted substrates. This protein has been shown to mediate the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Furthermore, RNF144A positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination, increasing its 'Lys-6'-linked ubiquitination, and facilitating its translocation from the endoplasmic reticulum to the Golgi. This ultimately leads to downstream signaling pathways. RNF144A also plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Additionally, this protein increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol. RNF144A exhibits self-association and interacts with UBE2L3.
RNF144A is also known as RNF144, UBCE7IP4, UIP4, hUIP4.
