RND2
Description
The RND2 (Rho family GTPase 2) is a protein-coding gene located on chromosome 17.
RND2 is a small (~21 kDa) signaling G protein, specifically a GTPase, belonging to the Rnd subgroup of the Rho family of GTPases. It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors. RND2 is implicated in the regulation of neuronal morphology and endosomal trafficking. The gene is located on chromosome 17, neighboring the BRCA1 gene involved in breast-ovarian cancer susceptibility. RND2 interacts with ARHGAP5, RACGAP1, and UBXD5.
RND2, also known as RhoN, Rho family GTPase 2, or Rho-related GTP-binding protein Rho7, is a member of the Rho subfamily of GTPases. It is insensitive to C3 toxin and may be specifically involved in neuronal and hepatic functions.
RND2 is also known as ARHN, RHO7, RhoN.
Associated Diseases
- glioblastoma
- Brugada syndrome
- atrial septal defect 7
- familial atrial fibrillation
- hypertrophic cardiomyopathy 6
- dilated cardiomyopathy 1AA
