RMND5B
Description
The RMND5B (required for meiotic nuclear division 5 homolog B) is a protein-coding gene located on chromosome 5.
RMND5B, also known as Required for meiotic nuclear division 5 homolog B (S. cerevisiae), is a protein encoded by the RMND5B gene. It is highly conserved throughout many eukaryotic organisms and contains a zinc finger domain, suggesting it interacts directly with DNA. It is rich in leucine and may belong to the protein family of leucine-rich repeats. This protein is highly expressed in tissues where meiosis occurs, such as the testis and ovaries, suggesting a role in the process of meiosis.
RMND5B is a core component of the CTLH E3 ubiquitin-protein ligase complex. It works with other proteins like MAEA and RMND5A to accept ubiquitin from UBE2H, which then leads to the tagging and degradation of the transcription factor HBP1. This process is essential for normal cell growth and proliferation. Interestingly, the CTLH complex doesn't seem to play a role in breaking down enzymes involved in gluconeogenesis, like FBP1.
RMND5B is also known as GID2, GID2B.
