RMI2
Description
The RMI2 (RecQ mediated genome instability 2) is a protein-coding gene located on chromosome 16.
RMI2 is a crucial part of the RMI complex, which is involved in processing homologous recombination intermediates. It plays a role in regulating sister chromatid segregation and limiting DNA crossover. RMI2 is essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. Within the RMI complex, RMI2 is required to target BLM to chromatin, stress-induced nuclear foci, and to mediate mitotic phosphorylation of BLM.
RMI2 is also known as BLAP18, C16orf75.
Associated Diseases
- cancer
- autoinflammatory syndrome with immunodeficiency
- carcinoma of liver and intrahepatic biliary tract
- systemic lupus erythematosus
- autoimmune thrombocytopenia
