RLN3


Description

The RLN3 (relaxin 3) is a protein-coding gene located on chromosome 19.

Relaxin-3 is a neuropeptide, highly conserved across species, discovered in 2001. It is part of the relaxin family of peptides, related to the hormone relaxin which affects pregnancy. Relaxin-3's primary receptor is RXFP3, but it can also interact with RXFP1 and RXFP3, though the physiological significance is unknown. It is composed of 51 amino acids in humans, arranged in two chains (A and B) linked by disulfide bonds. Relaxin-3 is primarily expressed in brain neurons, packaged in vesicles and transported along axons, suggesting neurotransmitter function. It is concentrated in the nucleus incertus of the brainstem, with smaller amounts in other areas. Relaxin-3 innervates various brain regions rich in RXFP3, including the limbic system and septohippocampal pathway, suggesting involvement in a wide range of behaviors.

RLN3 is also known as H3, RXN3, ZINS4, insl7.

Associated Diseases



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