RIOK1
Description
The RIOK1 (RIO kinase 1) is a protein-coding gene located on chromosome 6.
RIOK1 is a serine/threonine-protein kinase encoded by the RIOK1 gene in humans. It is an atypical protein found in most archaea and eukaryotes. RIOK1 is involved in the maturation of small ribosomal subunits (SSUs) and its overexpression or mutations may contribute to cancer initiation and progression. RIOK1 has a molecular weight of 65,583 Da, a predicted isoelectric point of 5.84, and is located on human chromosome 6p24.3. Post-translational modifications like methylation and phosphorylation can affect RIOK1's stability and biological functions, including cell growth. Mutations in RIOK1 can alter its biological properties.
RIOK1 is involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. It contributes to the processing of 18S-E pre-rRNA into the mature 18S rRNA and is essential for the recycling of NOB1 and PNO1 from the late 40S precursor. RIOK1's association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceding the binding to the 60S ribosomal subunit. Although RIOK1 possesses a protein kinase domain, it is thought to function primarily as an ATPase. Its catalytic activity regulates its dynamic association with the 40S subunit. Beyond its role in ribosomal biogenesis, RIOK1 acts as an adapter protein, recruiting NCL/nucleolin to the PRMT5 complex for its symmetrical methylation.
RIOK1 is also known as AD034, RIO1, RRP10, bA288G3.1.
