RICTOR
Description
The RICTOR (RPTOR independent companion of MTOR complex 2) is a protein-coding gene located on chromosome 5.
RICTOR (Rapamycin-insensitive companion of mammalian target of rapamycin) is a protein encoded by the RICTOR gene in humans. It is a component of the mTORC2 complex, which plays a crucial role in regulating cell growth in response to nutrient and growth factor signals. The RICTOR gene is located on chromosome 5 at 5p13.1 and encodes a protein with 1709 amino acids, which is present in the cytosol. While RICTOR contains few conserved regions, 21 phosphorylation sites have been identified, including T1135, which is phosphorylated in response to growth factors via S6K1. RICTOR is a key component of mTORC2, which, unlike mTORC1, is not directly inhibited by rapamycin.
RICTOR is a subunit of the mTORC2 complex, which plays a crucial role in regulating cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors and is insensitive to nutrient levels. mTORC2 regulates the actin cytoskeleton by activating Rho GTPases. It promotes the formation of stress fibers, plays a critical role in activating AKT1 by phosphorylating it at Ser-473, and regulates the phosphorylation of SGK1 and PRKCA. RICTOR is essential for embryonic growth and development.
RICTOR is also known as AVO3, PIA, hAVO3.
