RHOU
Description
The RHOU (ras homolog family member U) is a protein-coding gene located on chromosome 1.
RHOU acts upstream of PAK1, influencing the organization of the actin cytoskeleton, turnover of cell adhesions, and boosting cell migration. It triggers quiescent cells to re-enter the cell cycle. While lacking detectable GTPase activity, RHOU exhibits high intrinsic guanine nucleotide exchange activity, suggesting it is persistently bound to GTP. RHOU contributes to regulating cell morphology and cytoskeletal organization and is crucial for maintaining cell shape.
RHOU is also known as ARHU, CDC42L1, G28K, WRCH1, hG28K.
Associated Diseases
- skin cancer
- cancer
- endometrial cancer
- posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome
- Miyoshi myopathy
- dehydrated hereditary stomatocytosis
- microcytic anemia with liver iron overload
- hemoglobin D disease
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- autosomal recessive spondylocostal dysostosis
- hemoglobin E disease
