RHOT1
Description
The RHOT1 (ras homolog family member T1) is a protein-coding gene located on chromosome 17.
RHOT1, also known as MIRO1, is an enzyme encoded by the RHOT1 gene on chromosome 17. As a Miro protein isoform, RHOT1 facilitates mitochondrial transport by attaching mitochondria to the motor/adaptor complex. It plays a key role in mitochondrial homeostasis and apoptosis, and is involved in Parkinson's disease (PD) and cancer. RHOT1 is one of two Miro isoforms in mammals. Both isoforms share a structure consisting of two EF-hand motifs linking two GTP-binding domains and a C-terminal transmembrane domain that attaches the protein to the outer mitochondrial membrane (OMM). The EF-hand motifs serve as binding sites for the adaptor protein Milton and the kinesin heavy chain. These domains can also bind calcium ions, and binding results in a conformational change that dissociates the mitochondrial surface from kinesin.
RHOT1, also known as MIRO1 or hMiro-1, is a mitochondrial GTPase that plays a crucial role in mitochondrial trafficking. This protein is involved in the regulation of anterograde transport of mitochondria and their distribution within the cell. During high calcium conditions, RHOT1 promotes mitochondrial fission.
RHOT1 is also known as ARHT1, MIRO-1, MIRO1.
Associated Diseases
- ovarian cancer
- cataract
- refractive error
- esophageal cancer
- cancer
- type 2 diabetes mellitus
- Parkinson disease
