RGS7
Description
The RGS7 (regulator of G protein signaling 7) is a protein-coding gene located on chromosome 1.
RGS7, or Regulator of G-protein signaling 7, is a protein encoded by the RGS7 gene in humans. It is highly concentrated in the brain, acting as a universal inhibitor of Gi/o-coupled GPCRs. RGS7 is a GTPase-activating protein (GAP), accelerating GTP hydrolysis on G proteins. This speeds up their inactivation, acting as an intracellular antagonist of GPCR signaling.
RGS7, as part of the RGS7-GNB5 complex, acts as a regulator of G protein-coupled receptor (GPCR) signaling cascades. The complex functions as an inhibitor of signal transduction by enhancing the GTPase activity of G protein alpha subunits, such as GNAO1, transitioning them into their inactive GDP-bound state. RGS7's role in synaptic vesicle exocytosis is probable. GPR158-mediated regulation of the RGS7-GNB5 complex, dependent on glycine, influences mood and cognition by adjusting neuronal excitability within the prefrontal cortex's L2/L3 pyramidal neurons. RGS7 modulates potassium channel activity triggered by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.
RGS7 is also known as -.
