RGPD1
Description
The RGPD1 (RANBP2 like and GRIP domain containing 1) is a protein-coding gene located on chromosome 2.
RGPD1 is a gene that plays a vital role in regulating cell cycle progression and maintaining genomic integrity. It encodes a protein that functions in the G1/S transition, ensuring proper DNA replication and preventing uncontrolled cell growth. Furthermore, this protein participates in the DNA damage response pathway, helping cells repair damaged DNA.
RGPD1 is a highly conserved gene that encodes a protein involved in regulating the cell cycle and DNA replication. It plays a critical role in the G1/S transition, ensuring proper DNA replication and preventing uncontrolled cell growth. This protein also participates in the DNA damage response pathway, helping cells repair damaged DNA and maintain genomic integrity.
RGPD1 is also known as RGP1, RGPD2, RanBP2L2, ranBP2L6.
Associated Diseases
- isolated congenital hypogonadotropic hypogonadism
- 46,XY complete gonadal dysgenesis
- 46,XX testicular disorder of sex development
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
- myofibromatosis, infantile, 1
- BAP1-related tumor predisposition syndrome
- Li-Fraumeni syndrome
- familial atypical multiple mole melanoma syndrome
- familial male-limited precocious puberty
- Ollier disease
- partial chromosome Y deletion
- X-linked intellectual disability-macrocephaly-macroorchidism syndrome
- spermatogenic failures 50
- colorectal cancer, susceptibility to, 12
