REPIN1
Description
The REPIN1 (replication initiator 1) is a protein-coding gene located on chromosome 7.
REPIN1 (Replication Initiator 1) is a human protein encoded by the REPIN1 gene. It plays a key role in DNA replication, acting as a replication initiation-region protein. REPIN1 contains three zinc finger hand clusters, each with 15 zinc finger DNA-binding motifs, enabling its RNA binding activity. It is located in the nucleoplasm and is involved in regulating transcription through RNA polymerase II. REPIN1 is expressed in various tissues, including the colon, spleen, kidney, and 23 other human tissues.
REPIN1 was first identified in a study on dihydrofolate reductase gene (dhfr) replication in Chinese hamsters. The study found that REPIN1, then known as RIP60, initiated replication near stable bent DNA and bound to multiple factors. Its cofractionation with ATP-dependent DNA helicase suggested its involvement in chromosomal DNA synthesis in mammalian cells.
REPIN1 is located on chromosome 7q36.1. It acts as a specific sequence binding protein in human DNA, essential for the initiation of chromosomal replication.
REPIN1 is a sequence-specific DNA-binding protein that initiates chromosomal DNA replication. It binds to repeated 5'-ATT-3' sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence within the OBR zone. REPIN1 also facilitates DNA bending.
REPIN1 is also known as AP4, RIP60, ZNF464, Zfp464.
