RECK
Description
The RECK (reversion inducing cysteine rich protein with kazal motifs) is a protein-coding gene located on chromosome 9.
RECK, also known as reversion-inducing cysteine-rich protein with kazal motifs, is a human gene believed to be a metastasis suppressor. The protein it encodes is a cysteine-rich, extracellular protein with protease inhibitor-like domains. Its expression is significantly reduced in many tumors and cells transformed by various oncogenes. In normal cells, this membrane-anchored glycoprotein acts as a negative regulator of matrix metalloproteinase-9 (MMP-9), a key enzyme involved in tumor invasion and metastasis. It is one of the targets of an oncomiR, MIRN21.
RECK, along with ADGRA2, allows brain endothelial cells to respond specifically to Wnt7 signals (WNT7A or WNT7B). This role is essential for central nervous system (CNS) angiogenesis and the regulation of the blood-brain barrier. RECK acts as a Wnt7-specific coactivator in canonical Wnt signaling, decoding Wnt ligands by interacting with the disordered linker region of Wnt7. This selectivity is crucial for Wnt7 signaling. ADGRA2 then delivers RECK-bound Wnt7 to frizzled, forming a complex with RECK, ADGRA2, Fzd, LRP5, and LRP6. Additionally, RECK functions as a serine protease inhibitor. It negatively regulates matrix metalloproteinase-9 (MMP9) by reducing MMP9 secretion and directly inhibiting its enzymatic activity. It also inhibits the metalloproteinase activity of MMP2 and MMP14 (MT1-MMP).
RECK is also known as ST15.
Associated Diseases
- cancer
- ameloblastoma
- upper limb mesomelic dysplasia
- Gollop-Wolfgang complex
- congenital radioulnar synostosis
- radial hemimelia
- ring chromosome 4
- acheiropody
- femur-fibula-ulna complex
- breast cancer
- lethal faciocardiomelic dysplasia
- metaphyseal anadysplasia
- ulna hypoplasia-intellectual disability syndrome
