REC8
Description
The REC8 (REC8 meiotic recombination protein) is a protein-coding gene located on chromosome 14.
REC8 is a protein essential for proper chromosome segregation during meiosis. It is a component of the cohesin complex, which binds sister chromatids together. REC8 is sequentially removed from chromosomes, first from the arms during meiosis I, separating homologous chromosomes, and then from the centromeres during meiosis II, separating sister chromatids. REC8 interacts with other cohesin proteins, including STAG3, SMC1B, and SMC3, to ensure proper cohesion throughout meiosis.
REC8 is essential for proper chromosome segregation during meiosis. It ensures sister chromatids stay together until the appropriate time during meiosis I and II. During anaphase I, the protein is cleaved from chromosome arms by separin, enabling homologous chromosomes to separate. In anaphase II, REC8 is removed from centromeres, allowing sister chromatids to separate.
REC8 is also known as HR21spB, REC8L1, Rec8p.
Associated Diseases
- esophageal cancer
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 61
- spermatogenic failure 25
- spermatogenic failure 48
- spermatogenic failure, X-linked, 2
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 20
- spermatogenic failure 72
- ring chromosome Y
- spermatogenic failure 18
- spermatogenic failure 27
