RBMS1
Description
The RBMS1 (RNA binding motif single stranded interacting protein 1) is a protein-coding gene located on chromosome 2.
RBMS1 is a protein encoded by the RBMS1 gene in humans. It belongs to a family of proteins that bind to single-stranded DNA and RNA. These proteins have two sets of ribonucleoprotein consensus sequences (RNP-CS), which contain conserved motifs RNP1 and RNP2, essential for DNA binding. RBMS1 is involved in various cellular functions, including DNA replication, gene transcription, cell cycle progression, and apoptosis. It exists in different isoforms due to alternative splicing. Several RBMS1 isoforms have been identified based on their binding properties: some bind to the upstream element of the c-myc gene (MSSPs), others complement cdc2 and cdc13 mutants in yeast (scr2), and some act as potential human repressors of HIV-1 and ILR-2 alpha promoter transcription (YC1). A pseudogene for RBMS1 is located on chromosome 12. RBMS1 interacts with Polymerase (DNA directed), alpha 1.
RBMS1 is a single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. It binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3' and is likely involved in DNA replication.
RBMS1 is also known as C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1.
