RBM7
Description
The RBM7 (RNA binding motif protein 7) is a protein-coding gene located on chromosome 11.
RNA-binding motif protein 7 is a protein that in humans is encoded by the RBM7 gene. RBM7 has been shown to interact with SF3B2 and SFRS3.
RBM7 is a component of the nuclear exosome targeting (NEXT) complex, which acts as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for degradation. This complex plays a role in surveillance and turnover of aberrant transcripts and non-coding RNAs. RBM7 preferentially binds to polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates. It also participates in DNA damage response and stress response. During stress, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding, modulating the turnover of the non-coding transcriptome. In the DNA damage response, RBM7 interacts with MEPCE and LARP7, the core subunits of the 7SK snRNP complex, leading to the release of the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. This activation of the P-TEFb complex induces transcription of P-TEFb-dependent DDR genes, promoting cell viability.
RBM7 is also known as -.
Associated Diseases
- Senior-Boichis syndrome
- hepatorenocardiac degenerative fibrosis
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9
- nephronophthisis 3
- immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia
- idiopathic CD4 lymphocytopenia
- pulmonary fibrosis and/or bone marrow failure, Telomere-related, 3
- familial juvenile hyperuricemic nephropathy type 2
- breast cancer
