RBM4B
Description
The RBM4B (RNA binding motif protein 4B) is a protein-coding gene located on chromosome 11.
RBM4B is essential for activating the translation of PER1 mRNA, a crucial component of the circadian clock, in response to time-of-day cues. This activation is achieved through direct binding of RBM4B to the 3' untranslated region (3'-UTR) of the PER1 mRNA.
RBM4B is also known as RBM30, RBM4L, ZCCHC15, ZCCHC21B, ZCRB3B.
Associated Diseases
- diabetes mellitus, transient neonatal, 2
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- exercise-induced hyperinsulinism
- hyperinsulinemic hypoglycemia, familial, 2
- hyperinsulinism due to glucokinase deficiency
- histidinemia
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- renal cysts and diabetes syndrome
- hyperprolinemia type 1
- diabetes mellitus, permanent neonatal 4
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
- islet cell adenomatosis
- phosphoenolpyruvate carboxykinase deficiency, mitochondrial
- diabetes mellitus, transient neonatal, 3
- permanent neonatal diabetes mellitus 1
- pancreatic agenesis 2
