RBM24
Description
The RBM24 (RNA binding motif protein 24) is a protein-coding gene located on chromosome 6.
RBM24, also known as RNA-binding motif protein 24 or RNA-binding region-containing protein 6, is a multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability, and mRNA translation, which are important for cell fate decision and differentiation. It plays a major role in pre-mRNA alternative splicing regulation, mediating preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. It binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. It is involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. It plays a role in the regulation of mRNA stability. It binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities. It is involved in myogenic differentiation by regulating MYOG levels. It binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization. It promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence. It plays a role in the regulation of mRNA translation. It mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation. It binds to a huge amount of mRNAs. It is required for embryonic heart development, sarcomer and M-band formation in striated muscles. Together with RBM20, it promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes. It promotes hepatitis C virus (HCV) replication over translation through the inhibition of viral protein expression. It decreases viral translation by linking viral 5'- and 3'-UTRs, blocking 80S ribosome assembly on the viral IRES and enhancing the interaction of the mature core protein and 5'-UTR. It interacts with EIF4E; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex. It interacts with HCV mature core protein; this interaction, which enhances the interaction of Core with 5'-UTR may favor viral replication over translation. It interacts with HCV Serine protease/helicase NS3.
RBM24, also known as RNA-binding motif protein 24, is a multifunctional RNA-binding protein involved in regulating pre-mRNA splicing, mRNA stability, and mRNA translation. It plays a significant role in pre-mRNA alternative splicing regulation, mediating preferential muscle-specific exon inclusion in various mRNAs important for the differentiation of striated cardiac and skeletal muscle cells. It binds to intronic splicing enhancers (ISEs) composed of GU-rich motifs located in flanking introns of exons that are included by alternative splicing. RBM24 is involved in the transition of embryonic stem cells (ESCs) to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Furthermore, RBM24 regulates mRNA stability by binding to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, maintaining their stability. It is involved in myogenic differentiation by regulating MYOG levels. RBM24 binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, inducing its destabilization and promoting destabilization of CHRM2 mRNA through its binding to a region in the coding sequence. Additionally, RBM24 regulates mRNA translation. It mediates repression of p53/TP53 mRNA translation by binding to a U-rich element in the 3'-UTR, preventing EIF4E from binding to p53/TP53 mRNA and initiating translation. RBM24 binds to a vast amount of mRNAs and is essential for embryonic heart development, sarcomere, and M-band formation in striated muscles. Together with RBM20, it promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes.
RBM24 is also known as RNPC6, dJ259A10.1.
