RARG
Description
The RARG (retinoic acid receptor gamma) is a protein-coding gene located on chromosome 12.
Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene. Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.
== Interactions == Retinoic acid receptor gamma has been shown to interact with NCOR1.
RARG is a receptor for retinoic acid. It forms heterodimers with retinoid X receptors (RXRs) to bind to retinoic acid response elements (RAREs) in DNA, which are composed of tandem AGGTCA motifs. This binding regulates gene expression in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. In the absence of retinoic acid, RARG acts as an activator of gene expression due to weak binding to corepressors. RARG is required for the function of the growth plate in concert with other retinoic acid receptors, RARA and RARB.
RARG is also known as NR1B3, RARC, RARgamma.
