RAPGEF6

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Description

The RAPGEF6 (Rap guanine nucleotide exchange factor 6) is a protein-coding gene located on chromosome 5.

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.

RapGEF6 acts as a guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A, and M-Ras GTPases. It does not interact with cAMP.

RAPGEF6 is also known as KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2.

Associated Diseases

• asthma
• vein disorder
• male infertility with teratozoospermia due to single gene mutation