RAP2B
Description
The RAP2B (RAP2B, member of RAS oncogene family) is a protein-coding gene located on chromosome 3.
RAP2B is a protein encoded by the RAP2B gene in humans. It belongs to the Ras-related protein family. This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.
RAP2B is a small GTP-binding protein that cycles between an inactive GDP-bound state and an active GTP-bound state. It is involved in the EGFR and CHRM3 signaling pathways by stimulating PLCE1. RAP2B may also play a role in cytoskeletal rearrangements and cell spreading by activating the effector TNIK. It may regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}
RAP2B is also known as -.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- breast cancer
- type 2 diabetes mellitus
