RAP1GAP2
Description
The RAP1GAP2 (RAP1 GTPase activating protein 2) is a protein-coding gene located on chromosome 17.
RAP1GAP2 is a human protein encoded by the RAP1GAP2 gene. It functions as a GTPase-activating protein, activating the small guanine-nucleotide-binding protein Rap1, particularly in platelets. RAP1GAP2 interacts with synaptotagmin-like protein 1 and Rab27, playing a crucial role in regulating the release of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been identified for this gene.
Rap1GAP2 acts as a GTPase activator, specifically targeting the nuclear Ras-related regulatory protein RAP-1A (KREV-1). It facilitates the conversion of RAP-1A to its inactive GDP-bound state.
RAP1GAP2 is also known as GARNL4, RAP1GA3.
