RAP1B
Description
The RAP1B (RAP1B, member of RAS oncogene family) is a protein-coding gene located on chromosome 12.
RAP1B, also known as GTP-binding protein smg p21B, is a protein encoded by the RAP1B gene in humans.
RAP1B is a GTP-binding protein with intrinsic GTPase activity. It plays a crucial role in establishing and maintaining correct endothelial cell polarity and the vascular lumen. This is achieved by contributing to the polarizing activity of KRIT1 and CDH5. RAP1B is also required for the localization of phosphorylated PRKCZ, PARD3, and TIAM1 to the cell junction, contributing to the establishment of basal endothelial barrier function.
RAP1B is also known as K-REV, RAL1B, THC11.
