RAP1A
Description
The RAP1A (RAP1A, member of RAS oncogene family) is a protein-coding gene located on chromosome 1.
RAP1A is a human gene that encodes a protein belonging to the Ras-related protein family. These proteins share approximately 50% amino acid identity with classical RAS proteins and have numerous structural features in common. The main difference between RAP proteins and RAS proteins is the 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. RAP1A counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
RAP1A protein induces morphological reversion of a cell line transformed by a Ras oncogene. It counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, it regulates KRIT1 localization to microtubules and membranes. It plays a role in nerve growth factor (NGF)-induced neurite outgrowth. It also plays a role in the regulation of embryonic blood vessel formation and is involved in the establishment of basal endothelial barrier function. RAP1A may be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
RAP1A is also known as C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21.
