RAN
Description
The RAN (RAN, member RAS oncogene family) is a protein-coding gene located on chromosome 12.
RAN, or Ras-related nuclear protein, is a protein that in humans is encoded by the RAN gene. It is a GTP-binding nuclear protein involved in nucleocytoplasmic transport. RAN is also involved in mitotic spindle assembly and chromosome segregation.
RAN is a GTPase involved in nucleocytoplasmic transport, facilitating both the import and export of proteins and RNAs from the nucleus. It toggles between a cytoplasmic GDP-bound state and a nuclear GTP-bound state through nucleotide exchange and GTP hydrolysis. RAN interacts with import and export receptors to control cargo loading and release within the appropriate compartment, ensuring directional transport. In its GTP-bound form, RAN triggers microtubule assembly at mitotic chromosomes, essential for proper mitotic spindle assembly and chromosome segregation. It plays a crucial role in normal progression through mitosis, forming a complex with BIRC5/survivin to deliver the RAN effector molecule TPX2 to microtubules for mitotic spindle formation. RAN acts as a negative regulator of the kinase activity of VRK1 and VRK2, and it enhances AR-mediated transactivation, with transactivation decreasing as the poly-Gln length within AR increases.
RAN is also known as ARA24, Gsp1, TC4.
