RAB4B-EGLN2
Description
The RAB4B-EGLN2 (RAB4B-EGLN2 readthrough (NMD candidate)) is a ncRNA gene located on chromosome 19.
RAB4B-EGLN2 is a gene located on chromosome 19 that encodes a protein called EGLN2. EGLN2 is a prolyl hydroxylase that is involved in the regulation of oxygen homeostasis. It acts by catalyzing the hydroxylation of hypoxia-inducible factor-1 alpha (HIF-1α) under normoxic conditions, which targets HIF-1α for proteasomal degradation. This degradation prevents the accumulation of HIF-1α and the subsequent activation of hypoxia-responsive genes. In hypoxic conditions, EGLN2 activity is reduced, allowing HIF-1α to accumulate and promote the expression of genes involved in oxygen delivery and metabolism. Therefore, RAB4B-EGLN2 plays an important role in regulating cellular adaptation to oxygen deprivation.
RAB4B-EGLN2 is a gene that encodes a protein involved in the regulation of oxygen homeostasis. The protein, EGLN2, is a prolyl hydroxylase that catalyzes the hydroxylation of hypoxia-inducible factor-1 alpha (HIF-1α) under normoxic conditions. This hydroxylation targets HIF-1α for proteasomal degradation, preventing its accumulation and the activation of hypoxia-responsive genes. In hypoxic conditions, EGLN2 activity is reduced, allowing HIF-1α to accumulate and promote the expression of genes involved in oxygen delivery and metabolism. RAB4B-EGLN2 is therefore an important regulator of cellular adaptation to oxygen deprivation.
RAB4B-EGLN2 is also known as EGLN2, EIT-6, EIT6, HIF-PH1, HPH-1, HPH-3, PHD1, RERT-lncRNA.
