RAB38
Description
The RAB38 (RAB38, member RAS oncogene family) is a protein-coding gene located on chromosome 11.
Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.
RAB38 plays a role in the transport and docking of melanosomes, particularly in the proper sorting and peripheral distribution of TYRP1 within melanocytes. This process likely involves vesicle trafficking and collaboration with ANKRD27 and VAMP7. RAB38 also contributes to the maturation of phagosomes, which engulf pathogens such as S.aureus and M.tuberculosis. It significantly impacts the regulation of melanin production and melanosome biogenesis. In partnership with RAB32, RAB38 ensures the correct trafficking of melanogenic enzymes TYR, TYRP1, and DCT/TYRP2 to melanosomes in melanocytes.
RAB38 is also known as NY-MEL-1, rrGTPbp.
Associated Diseases
- intracranial thrombosis
- Griscelli syndrome type 3
- ringed hair disease
- uncombable hair syndrome
- microcephaly-albinism-digital anomalies syndrome
- pili bifurcati
- glioblastoma
