RAB35
Description
The RAB35 (RAB35, member RAS oncogene family) is a protein-coding gene located on chromosome 12.
Ras-related protein Rab-35 is a protein that in humans is encoded by the RAB35 gene.
RAB35, also known as GTP-binding protein RAY or Ras-related protein Rab-1C, is a small GTPase that plays a crucial role in regulating intracellular membrane trafficking. It cycles between an inactive GDP-bound form and an active GTP-bound form, which recruits downstream effectors to membranes to regulate vesicle formation, movement, tethering, and fusion. RAB35 is involved in endocytosis and is essential for the fast recycling pathway back to the plasma membrane. It also plays a critical role in cytokinesis, specifically in the post-furrowing terminal steps, stabilizing the intercellular bridge and promoting abscission, potentially by controlling the localization of phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 at the intercellular bridge. Additionally, RAB35 may indirectly regulate neurite outgrowth and, in conjunction with TBC1D13, could regulate the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the plasma membrane in adipocytes.
RAB35 is also known as H-ray, RAB1C, RAY.
Associated Diseases
- early-onset non-syndromic cataract
- isolated ectopia lentis
- hereditary hyperferritinemia with congenital cataracts
- cataract 13 with adult I phenotype
- cataract 38
- cataract
- cochleosaccular degeneration-cataract syndrome
- X-linked endothelial corneal dystrophy
- congenital cataract-ichthyosis syndrome
- Lisch epithelial corneal dystrophy
