RAB31
Description
The RAB31 (RAB31, member RAS oncogene family) is a protein-coding gene located on chromosome 18.
Ras-related protein Rab-31 is a protein that in humans is encoded by the RAB31 gene.
Rab proteins are essential regulators of intracellular membrane trafficking, controlling steps from vesicle formation to fusion with target membranes. Rab31, like other Rab GTPases, cycles between inactive GDP-bound and active GTP-bound states, recruiting different effectors to membranes to orchestrate vesicle formation, movement, tethering, and fusion. Rab31 is crucial for maintaining the integrity and function of the Golgi apparatus and the trans-Golgi network. It plays a role in insulin-stimulated GLUT4 translocation to the cell membrane, M6PR transport from the trans-Golgi network to endosomes, and EGFR internalization from the cell membrane into endosomes. Additionally, Rab31 contributes to the maturation of phagosomes responsible for engulfing pathogens such as S. aureus and M. tuberculosis.
RAB31 is also known as Rab22B.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- type 2 diabetes mellitus
- schizophrenia 15
- cancer
