RAB2B
Description
The RAB2B (RAB2B, member RAS oncogene family) is a protein-coding gene located on chromosome 14.
RAB2B is a human protein encoded by the RAB2B gene. It is a member of the small GTPase superfamily, specifically the RAB protein family. Small GTPases are hydrolases that can bind to GTP to become active or GDP to become inactive. RAB2B is responsible for transporting proteins from the endoplasmic reticulum to the Golgi complex. RAB2B is located on chromosome 14 and contains a core of oxygen, carbon, nitrogen, and phosphorus. Its structure includes eight alpha helices and six beta strands, along with a magnesium ion and GDP. Mature RAB2B has three post-translational modifications: a phosphoserine at position 202 and two lipidations at positions 215-216.
RAB2B is a small GTPase that plays a crucial role in regulating intracellular membrane trafficking. It controls the movement of transport vesicles from their origin to their target locations, ensuring proper organelle structure and function. RAB2B is also involved in immune responses, specifically by promoting innate immune responses triggered by DNA in the cytoplasm and regulating interferon responses against DNA viruses. It contributes to the compacted morphology of the Golgi apparatus and aids in efficient autophagy.
RAB2B is also known as -.
