RAB22A
Description
The RAB22A (RAB22A, member RAS oncogene family) is a protein-coding gene located on chromosome 20.
RAB22A is a member of the RAB family of small GTPases, which are known for their roles in regulating vesicular trafficking. The GTP-bound form of RAB22A interacts with early-endosomal antigen 1 (EEA1), suggesting its involvement in the trafficking and communication between endosomal compartments.
RAB22A plays a crucial role in regulating endocytosis and intracellular protein transport. It mediates the movement of transferrin (TF) from early endosomes to recycling endosomes, facilitating the recycling of iron-carrying proteins. Notably, RAB22A is essential for nerve growth factor (NGF)-mediated endocytosis of the NTRK1 receptor, a process critical for neurite outgrowth and neuronal development. RAB22A binds to both GTP (active form) and GDP (inactive form), exhibiting low GTPase activity, which allows it to switch between active and inactive states.
RAB22A is also known as -.
