PTPRZ1
Description
The PTPRZ1 (protein tyrosine phosphatase receptor type Z1) is a protein-coding gene located on chromosome 7.
PTPRZ1, also known as phosphacan, is a human enzyme encoded by the PTPRZ1 gene. It belongs to the receptor tyrosine phosphatase family and is a single-pass type I membrane protein with multiple domains including tyrosine-protein phosphatase domains, a carbonic anhydrase domain, and a fibronectin type III domain. PTPRZ1 expression is induced in various conditions such as gastric cancer, remyelinating oligodendrocytes in multiple sclerosis lesions, and human embryonic kidney cells under hypoxia. Overexpression of PTPRZ1 has been observed in glioblastoma cells, promoting their migration.
PTPRZ1 is also known as HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan.
Associated Diseases
- schizophrenia
- extraskeletal myxoid chondrosarcoma
- cancer
- glioblastoma
- myofibromatosis, infantile, 1
- chordoma
- Ollier disease
