PTPRK
Description
The PTPRK (protein tyrosine phosphatase receptor type K) is a protein-coding gene located on chromosome 6.
PTPRK, also known as PTPkappa and PTPκ, is an enzyme encoded by the PTPRK gene in humans. It belongs to the protein tyrosine phosphatase (PTP) family, which removes phosphate groups from tyrosine residues on other proteins, playing a crucial role in cellular signaling. PTPs are involved in various processes, including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. The PTPRK gene is located on the long arm of chromosome 6, a region associated with tumor suppression. In developmental studies, a transgenic mouse model using a β-galactosidase reporter gene and the transmembrane domain of the CD4 protein revealed the importance of PTPRK in mouse development.
PTPRK plays a critical role in regulating processes related to cell-cell interactions, including growth control, tumor invasion, and metastasis. It acts as a negative regulator of the EGFR signaling pathway, which is implicated in cell growth and proliferation. PTPRK forms complexes with beta-catenin and gamma-catenin/plakoglobin, suggesting its involvement in cell adhesion and cytoskeletal organization. Furthermore, beta-catenin may be a substrate for PTPRK's catalytic activity, indicating its potential role in regulating beta-catenin signaling.
PTPRK is also known as R-PTP-kappa.
Associated Diseases
- desmoplastic melanoma
- carcinoma of liver and intrahepatic biliary tract
- superficial spreading melanoma
- pancreatic ductal adenocarcinoma
