PTPN7
Description
The PTPN7 (protein tyrosine phosphatase non-receptor type 7) is a protein-coding gene located on chromosome 1.
PTPN7, or Protein tyrosine phosphatase non-receptor type 7, is an enzyme encoded by the PTPN7 gene in humans. It belongs to the protein tyrosine phosphatase (PTP) family, which regulates cellular processes like growth, differentiation, cell cycle, and oncogenic transformation. PTPN7 is mainly expressed in hematopoietic cells and is an early response gene in cells stimulated by lymphokines. Its noncatalytic N-terminus interacts with MAP kinases and suppresses their activity. PTPN7 is involved in regulating T cell antigen receptor (TCR) signaling, possibly through dephosphorylating molecules in the MAP kinase pathway. Two isoforms of this gene are created through alternative splicing. PTPN7 has been shown to interact with MAPK3 and MAPK1.
PTPN7 is also known as BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI.
