PTGR1
Description
The PTGR1 (prostaglandin reductase 1) is a protein-coding gene located on chromosome 9.
PTGR1, also known as prostaglandin reductase 1 (PRG-1), is a NAD(P)H-dependent oxidoreductase involved in the metabolic inactivation of various pro- and anti-inflammatory eicosanoids, including prostaglandins (PG), leukotrienes (LT), and lipoxins (LX). It primarily catalyzes the reduction of the 13,14 double bond in 15-oxoPGs, such as 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha, and 15-oxo-PGF2-alpha. It also oxidizes the hydroxyl group at C12 of LTB4 and its derivatives, converting them into less active 12-oxo-LTB4 metabolites. PTGR1 further reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, potentially enhancing neutrophil recruitment during inflammation. Additionally, PTGR1 might contribute to the metabolic detoxification of alkenals and ketones by reducing alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, displaying a high affinity for (2E)-decenal and (3E)-3-nonen-2-one. It may also inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid component found in oxidized low-density lipoprotein particles.
PTGR1 is also known as DIG-1, LTB4DH, PGR1, ZADH3.
