PTCRA
Description
The PTCRA (pre T cell antigen receptor alpha) is a protein-coding gene located on chromosome 6.
The pre-T-cell receptor complex, which includes PTCRA, TCRB, and the CD3 complex, plays a crucial role in the early stages of T-cell development.
PTCRA is also known as PT-ALPHA, PTA.
Associated Diseases
- lymphopenia
- substance abuse
- Okt4 epitope deficiency
- combined immunodeficiency with skin granulomas
- 22q11.2 deletion syndrome
- neutropenia, severe congenital, 2, autosomal dominant
- immunodeficiency 19
- T-cell immunodeficiency, congenital alopecia, and nail dystrophy
- T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant
- epidermodysplasia verruciformis
- common variable immunodeficiency
- combined immunodeficiency due to partial RAG1 deficiency
- short-limb skeletal dysplasia with severe combined immunodeficiency
- severe combined immunodeficiency due to IKK2 deficiency
